![]() This could mean that they could even find something as small as a prick to the finger extremely painful. Heightened pain sensitivity or opioid-induced hyperalgesia is when a patient that’s being given opioids for pain management, instead of feeling less pain overall, ends up being hypersensitive to pain instead. These have shown a literal decrease in emotional pain. In another study, MRI scans were done of the brains of subjects taking Acetaminophen, and they showed decreased activity in parts of the brain that respond to emotional stress. Those who took Acetaminophen showed that they were feeling less hurt than those who took the placebo pill. Sixty-two subjects were given either an acetaminophen/ hydrocodone or a placebo pill. In a 2011 study, it was found that Acetaminophen doesn’t just hinder physical pain, but somehow emotional pain as well. However, Acetaminophen is a component that’s present in addictive opioids like Vicodin and Percocet. Painkillers like Acetaminophen, aren’t drugs that people use recreationally, they’re not even required to be prescribed by a doctor, which is why it’s hard to think of them having a significant effect on the patient’s health or the brain. Too much of it can be toxic for the liver and cause damage. One of the main dangers of taking the medication is that too much of the Acetaminophen’s metabolite, NAPQI, can cause the glutathione pathway to get overwhelmed with NAPQI. Effects on the LiverĮven though Acetaminophen is harmless when it’s taken in low doses, it can be dangerous to health if the user uses too much of it. ![]() Generally, patients prescribed over 2.6 g/day were at higher risk of GI bleeding than those who didn’t. Although, this is also dependent on pre-existing GI risk factors. This can happen even without an overdose happening. The use has been associated with a particularly increased risk of patients getting gastrointestinal bleeding. Research has shown a relatively small degree of dose-dependence that comes with the prolonged use of medications that have acetaminophen/hydrocodone. Incomplete evacuation when passing stool. ![]() ![]() Possible Symptoms of Opioid-Induced Bowel Dysfunction May Include: When opioids cause issues with this particular system, it is often referred to as opioid-induced bowel dysfunction. Various complications can develop when a person’s gut is affected by these side effects. The use of opioids, including this particular drug, may also cause side effects on the gastrointestinal system. Some of the less common adverse effects of Norco may be harmful to the body. Those who take a higher dose of the drug should consider some of the rarer adverse reactions. Specific contraindications also exist, where the drug may lead to adverse effects if the person suffers from a particular health condition. When this medicine is taken along with certain drugs, Norco side effects may become more severe. In addition to considering these adverse reactions, individuals also need to consider Norco drug interactions. Those Who Take Norco May Also Experience These Side Effects: The most common side effect among patients who use the drug seems to be lightheadedness. Some side effects of Norco 5-325 and other strengths that the drug comes in are more common among people who use the medicine than others. While some Norco side effects may be mild, there are more serious adverse health effects to be noted as well. ![]() Individuals who are looking to use the medicine should understand the side effects of Norco. Norco headache relief, joint pain alleviation, and the use of the product for other symptoms may yield side effects. Hydrocodone remains one of the most commonly prescribed types of opioids in the country. Norco has become a widespread product among the US population, combining acetaminophen and hydrocodone bitartrate for a more potent alleviation of pain symptoms. Individuals experiencing pain symptoms have several options to opt for when it comes to finding relief. ![]()
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